Stephen P. Stone, MD, FAAD American Academy of Dermatology Association

“While the Academy welcomes additional and ongoing safety data on hydroquinone from manufacturers, a review of current data demonstrates that the benefits of these treatments are high and the risks minimal.”

“Accordingly, the Academy recommends no change in the status of either over-the-counter or prescription hydroquinone containing products.”

SOURCE: Letter to the Commissioner of Food and Drugs, U.S. Food and Drug Administration, December 27, 2006


Dr. Susan Taylor, Founding Director of the Skin of Color Center in New York City and Assistant Professor of Dermatology at Columbia University

“Hydroquinone is the gold standard for treating pigmentation disorders and has been for many years…I consider it to be very safe and effective.”

SOURCE: Pittsburgh Post-Gazette September 6, 2006


Howard I. Maibach, M.D. Professor of Dermatology at the University of California School of Medicine, San Francisco

“Overall, adverse events reported with the use of hydroquinone… have been relatively few and minor in nature…hydroquinone is undoubtedly the most active and safest skin-depigmenting substance.”

SOURCE: Journal of Toxicology and Environmental Health, 1998, pages 301-317


Dr. Pearl Grimes, Director of the Vitiligo and Pigmentation Institute of Southern California

“Trials of topical hydroquinone treatments have provided substantial data on the efficacy and safety of this treatment, extending over 40 years of use. The reported adverse effects of topically applied hydroquinone are all minor such as skin irritation, hyper- and hypo-pigmentation, ochronosis and nail discoloration. Importantly, no cases of carcinogenesis have been reported in over 40 years of the clinical use of topical hydroquinone.”

“Pigment disorders, while not life threatening, can have a significant psychological impact on those who are disfigured by multicolored skin. Hydroquinone has long been regarded by dermatologists as the gold standard in the treatment of certain pigmentary disorders of the skin. It is an effective treatment that provides improvements in both appearance and quality of life.”

SOURCE: Letter to the editor, Journal of Cosmetic Dermatology